primary drug-resistance

The primary goal of the strategy is to selectively increase tumor cell exposure to cytotoxic drug metabolites generated locally by a prodrug-activating P450 enzyme, which expresses highly in tumor cells after being transduced.

这种方法的首要目标就是选择性地使细胞色素P450在肿瘤细胞内超量表达。

Methods Sixty seven cases of primary generalized tonic clonic seizure with single PHT therapy were investigated. Adjustment of PHT dose depended on clinical effects and drug concentrations in serum and the efficacy was observed for more than half an year.

方法选择苯妥英钠单药治疗的原发性全身强直一阵挛性发作（PGTCS）患者67例，根据临床效果，结合实测血药浓度，调整剂量，至少观察半年判断临床疗效。

A Primary Study on Relationship between Self Admission and Psychological Health for Forced Drug Abstainers

强制戒毒者自我接纳与心理健康关系初步研究

Sleep health education is primary in all kinds of non-drug treatments, and is related to life style and environment.

睡眠卫生教育是各种非药物治疗的基础，涉及生活方式和环境因素；

Patients with primary myelofibrosis feel fatigued, and they sometimes take an anemia drug to stimulate growth of oxygen-carrying red blood cells.

初期骨髓纤维化的患者容易感觉疲劳，他们有时会服用贫血药来袭击携氧红细胞的生长。